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A Dengue vaccine by 2015?
- Written by Super User
Sri Lanka will have an anti dengue vaccine by 2015. This is the promise held out by health officials who say that so far all other methods of controlling the spread of dengue have not proved effective.
“A vaccine to fight dengue has now been developed. Trials are being conducted and by 2015, we hope to make this vaccine available to the public”, Dr Paba Pallihawardene , Head of the Entomological Department of the Ministry of Health, told The Nation. She said that while the mortality rates had reduced by fifty percent this year due to, ‘ high density training , awareness raising and new testing devices in the country, the number of cases islandwide has not decreased as expected. In fact, we have more cases than the previous year with 11,250 for the first four months and 55 deaths.
This is in spite of all the cleaning up operations, improved garbage disposal, and fogging, spraying BTI etc, and surveillance of all mosquito high risk places. Since we have so many waterways in this country, it is impossible for us to get rid of them all. Mosquitoes have also found new places to breed in cemented wells instead of the usual home gardens. So a vaccine can go a long way to pre vent the disease spreading.”
She said that thanks to the Police several errant mosquito breeders had been charge and fined. Police sources have been reported as saying that for the first quarter of the year there were 2191 dengue related arrests and nearly four million rupees was collected as fines from mosquito breeders.
Dengue Fever Symptoms
According to data from epidemiology unit of Sri Lanka, the number of total cases recorded for year 2009 is 32713. Most affected district was Kandy. Colombo, Gampaha and Kaluthara districts which have been susceptible in the past have also recorded a high rate of infection and deaths.
- Incubation period is 2-7 days.
- All haemorrhagic fever syndromes begin with abrupt onset of fever (39.5–41ºC) and myalgia.
- Fever is often biphasic with two peaks.
- Fever is associated with frontal or retro-orbital headache lasting 1–7 days, accompanied by generalised macular, blanching rash.
- Initial rash usually fades after 1–2 days.
- Symptoms regress for a day or two then rash reappears in maculopapular, morbilliform pattern, sparing palms and soles of feet. Fever recurs but not as high. There may be desquamation.
- DF cases experience severe bony and myalgic pain in legs, joints and lower back which may last for weeks (hence breakbone fever).
- Nausea, vomiting, cutaneous hyperaesthesia, taste disturbance and anorexia are common.
- Abdominal pain may occur and if severe suggests DHF pattern.The signs of dengue fever/ Dengue haemorrhagic fever are- High fever, rash, hypotension and narrow pulse pressure, poor capillary refill.
- There may be hepatomegaly and lymphadenopathy.
- A tourniquet placed on an arm may induce petechiae in early DHF cases. DHF sufferers exhibit a bleeding tendency as evidenced by petechiae, purpura, epistaxis, gum bleeding, GI haemorrhage and menorrhagia. There may be pleural effusion, ascites and pericarditis due to plasma leakage.
- Petechiae are best visualised in the axillae.
- Flushing of head and neck.
- Tender muscles on palpation.
- Periorbital oedema and proteinuria may be present.
- Maculopathy and retinal haemorrhages may also occur.
- DSS pattern cases progress through DHF until profound shock due to severe hypotension is present.
- CNS involvement e.g. encephalopathy, coma, convulsions.
- Hepatic failure: Means failure of the liver
- Encephalopathy: Means damage to the brain causing fits, loss of consciousness and confusion- Myocarditis – Inflamation of heart muscles
- Disseminated intravascular coagulation - Damage to blood vessels and blood cells causing problematic bleeding and clottingDengue can cause death
- Infection may be confirmed by isolation of virus in serum and detection of IgM and IgG antibodies for Dengue by ELISA, monoclonal antibody or haemagglutination
- Molecular diagnostic methods such as reverse-transcriptase-PCR are increasingly being used.
- Chest X-ray may show pleural effusion.
- Nutritious diet and lot of liquids, But avoid red and brown foods and drinks like coffee, chocolate, grapes etc as it may misinterpret vomiting as blood stained vomitus.
- Fever control with paracetamol, tepid sponging and fans. Aspirin should be avoided.
- Need to seek advice from a qualified medical practitioner if fever lasts for more than 2 days
- Hospital managemnt includes intravenous fluid resuscitation with close monitoring. Haemorrhage and shock will require Fresh Frozen Plasma, platelets and blood. Intensive management with inotropes of the shock syndrome may be required in severe DHF/DSS cases.
- Anti-mosquito public health measures such as reducing breeding sites ( flower pots, fish tanks,tires, coconut shells, tins, water collecting plants, gutters which can collect water) and good sewage management
- Insecticides to destroy the larvae
- Mosquito nets can be used during day time as the Aedes mosquitoes is day-biting.
- Mosquita repellents
- There is a bacteria called Bacillus thuringiensis which destroy the mosquito larvea